An endocrine-hepato-muscular metabolic cycle links skeletal muscle atrophy and hyperglycemia in type 2 diabetes
J. G. Okun, P. M. Rusu, A. Y. Chan, Y. W. Yap, T. Sharkie, J. Schumacher, S. Hille, K. Schmidt, A. Zota, A. Jungmann, L. Maggi, Y. Lee, M. Blueher, S. Herzig, M. Heikenwaelder, , A. J. Rose
This study identifies an endocrine-hepato-muscular metabolic cycle linking hyperglycemia and skeletal muscle atrophy in type 2 diabetes through dysregulated alanine metabolism and ALT enzyme activity.
bioRxiv · May 25, 2020 · PreprintPhysiology