Author

Aaron Orgel

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

Alyssa R. Fishbein· 1 shared Anton Davydenko· 1 shared Brennen Keuchel· 1 shared Diego Capcha-RodrigueziD· 1 shared Erez Y. LevanoniD· 1 shared Eric K.F. DonahueiD· 1 shared Ilana BuchumenskiiD· 1 shared James Jeiwen ChouiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperBiochemistry

Alyssa R. Fishbein

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

ER discontinuities are common in C. elegans neurons, revealing a genetically tractable model for ER network maintenance

Kelsey N Mabry, Eric K.F. Donahue, Aaron Orgel, Brennen Keuchel, Max Kushner, Kristopher Burkewitz

The paper shows that ER discontinuities are common in healthy C. elegans neurons and links their frequency to age, stress, and ER shaping factors.

bioRxiv · Apr 2, 2026 · PreprintCell Biology

PACT prevents aberrant activation of PKR by endogenous dsRNA without sequestration

Sadeem Ahmad, Tao Zou, Jihee Hwang, Linlin Zhao, Xi Wang, Anton Davydenko, Ilana Buchumenski, Patrick Zhuang, Alyssa R. Fishbein, Diego Capcha-Rodriguez, Aaron Orgel, Erez Y. Levanon, Sua Myong, James Jeiwen Chou, Matthew M. Meyerson, Sun Hur

This study shows PACT inhibits PKR activation by endogenous dsRNA through restricting PKR movement on dsRNA, without sequestering dsRNA, thereby adjusting the activation threshold for long dsRNA.

Nature Communications · Apr 8, 2025Peer-reviewedBiochemistry