BiochemistryNature CommunicationsPeer-reviewed
PACT prevents aberrant activation of PKR by endogenous dsRNA without sequestration
Sadeem Ahmad, Tao Zou, Jihee Hwang…·Sun Hur
This study shows PACT inhibits PKR activation by endogenous dsRNA through restricting PKR movement on dsRNA, without sequestering dsRNA, thereby adjusting the activation threshold for long dsRNA.
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