Sua Myong

This study identifies RNA G-quadruplexes as tunable regulators of FUS phase separation, showing they can inhibit or nucleate aggregation depending on structure and concentration.

The paper identifies short RNAs that prevent and reverse pathological fibrillization of RNA-binding proteins like FUS and TDP-43, showing therapeutic potential for ALS/FTD.

The paper shows PAR induces a conformational switch in FUS, enabling sustained condensation through N-terminal PrLD interactions after PAR degradation.

This study investigates the mechanisms of DNA and RNA strand transfer and protein exchange between SSB and RPA using smFRET, revealing dynamic interactions and length-dependent behavior.

The paper develops a single-molecule platform to study DNA supercoiling effects on protein-DNA interactions, finding that negative supercoiling increases Cas9 off-target effects and enhances MutS binding to mismatched bases.

This study shows PACT inhibits PKR activation by endogenous dsRNA through restricting PKR movement on dsRNA, without sequestering dsRNA, thereby adjusting the activation threshold for long dsRNA.

This study shows 6-thio-dG inhibits telomerase by forming a non-productive complex, affecting telomere maintenance in cancer cells.

This study shows that TDP-43 represses a cryptic exon in UNC13A, and genetic variants associated with FTD/ALS increase cryptic exon inclusion when TDP-43 is dysfunctional.