PRLX-93936 and BMS-214662 are cytotoxic molecular glues that leverage TRIM21 to degrade nucleoporins
Marc A Scemama de Gialluly, Anthony R. Allen, Elijah H Hayes, Patrick Zhuang, Ralston B. Goldfarb, Amanda N. Farrar, Yuriy Federov, Drew Adams
The paper identifies PRLX-93936 and BMS-214662 as molecular glues that use TRIM21 to degrade nucleoporins, leading to cell death and potential therapeutic applications in TRIM21-high cancers.
Nature Communications · Jul 16, 2025Peer-reviewedPharmacology & Toxicology