Cell BiologyiSciencePeer-reviewed
Pancreatic islet cell stress induced by insulin-degrading enzyme deficiency promotes islet regeneration and protection from autoimmune diabetes
Shuaishuai Zhu, Emmanuelle Waeckel-Énée, Masaya Oshima…·Peter Van Endert
This study shows that IDE deficiency in mice causes a low-level UPR, enhances beta cell proliferation, and protects against autoimmune diabetes through an anti-inflammatory pathway.
4 citations