Author

Abdul M. Naqvi

Western University

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1

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Adrianna R Tsang· 1 shared Claudia SeahiD· 1 shared Jordan M KrupaiD· 1 shared Manoj Reddy MedapatiiD· 1 shared Stephen PasternakiD· 1 shared

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2025-2025 · peak 1/yr

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1 shared paperNeuroscience

Adrianna R Tsang

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1 paper

Recent·Most cited

NeurosciencebioRxivPreprintMar 2, 2025

Macropinocytosis of amyloid precursor protein requires the adaptor protein Fe65 and the recruitment and activity of Arf6 and the RhoGTPases Rac1, Cdc42 and RhoA.

Jordan M Krupa, Abdul M. Naqvi, Manoj Reddy Medapati…·Stephen Pasternak

The paper demonstrates that Fe65 links APP to Arf6 and RhoGTPases to regulate macropinocytosis, which is critical for Aβ production in Alzheimer's disease.

DOI 10.1101/2025.03.02.641070

humanexperimental assay

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