Manoj Reddy Medapati

This study finds increased circulating TREM2+ microglia extracellular vesicles in aged APP/PS1 rats linked to cognitive impairment.

The paper demonstrates that Fe65 links APP to Arf6 and RhoGTPases to regulate macropinocytosis, which is critical for Aβ production in Alzheimer's disease.

This study shows that Arf6 and RhoGTPases Rac1, Cdc42, and RhoA are required for macropinocytosis of Aβ42 oligomers and tau fibrils in neurons, suggesting new targets to prevent their transfer in Alzheimer's disease.

This study shows that lysosomal exocytosis releases amyloid beta from hiPSC-derived neurons, suggesting it as a therapeutic target for Alzheimer's disease.

This study shows that T2R14 downregulates autophagy flux in gingival epithelial cells and that S. mutans CSP-1 induces calcium release dependent on T2R14 and autophagy protein 7.