ImmunologybioRxivPreprint
Novel engraftment and T cell differentiation of human hematopoietic cells in Art-/- IL2RG-/ SCID pigs
Adeline N Boettcher, Yunsheng Li, Amanda P. Ahrens…·Christopher K. Tuggle
The paper generates a T-B-NK-SCID pig model via CRISPR/Cas9 and demonstrates successful human hematopoietic cell engraftment in blood and lymphoid organs after in utero injection.
DOI 10.1101/614404