Author

Alessia Fisher

UK Dementia Research Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Adrian M. IsaacsiD· 1 shared Ahad A. RahimiD· 1 shared Alexander J. CammackiD· 1 shared Alexander McGowniD· 1 shared Alla MikheenkoiD· 1 shared Alyssa N. CoyneiD· 1 shared Benedikt V. Hölbling· 1 shared Bhavana MuralidharaniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Adrian M. IsaacsORCID

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2 papers

Recent·Most cited

NeuroscienceTranslational NeurodegenerationPeer-reviewedJun 17, 2026

Targeting Lysosomal pH Restores Mitochondrial Quality Control in GBA1-Mutant Parkinsons Disease

Preethi Sheshadri, Maria A. Costa-Besada, Alessia Fisher…·Michael R. Duchen

This study shows that targeting lysosomal pH with rapamycin or acidic nanoparticles restores mitochondrial function in GBA1-mutant Parkinson's disease neurons.

5 citationstop 1%

humanbulk RNA-seq

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NeuroscienceNature CommunicationsPeer-reviewedJan 8, 2025

Dual-targeting CRISPR-CasRx reduces C9orf72 ALS/FTD sense and antisense repeat RNAs in vitro and in vivo

Liam Kempthorne, Deniz Vaizoglu, Alexander J. Cammack…·Adrian M. Isaacs

This study demonstrates that CRISPR-CasRx reduces C9orf72 repeat RNAs and DPRs in vitro and in vivo, suggesting its therapeutic potential for ALS/FTD.

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humanmouse

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