IL-1β and TNF drive endothelial dysfunction and coagulopathy in acute COVID-19.
Helen Mostafavi, Brittany Hill, Christina Nalkurthi, Stefanie M. Bader, Yanshan Zhu, Alexander Yu, Philip M. Hansbro, Marcel Doerflinger, Matt D. Johansen, Kirsty Renfree Short, Keng Yih Chew, Emma J. Gordon, Larisa I. Labzin
This study identifies TNF and IL-1β as key drivers of endothelial dysfunction and coagulopathy in acute SARS-CoV-2 infection using in vitro and in vivo models.
bioRxiv · Mar 25, 2026 · PreprintCell Biology