Ivar Noordstra

This study introduces a new method to measure energy dissipation during cell-cell junction rupture and shows that cortical tension and shape relaxation time determine whether junctions behave ductile or brittle.

This study shows that c-Src is essential for neovascular tuft formation in Oxygen-Induced Retinopathy, as its depletion reduces tuft formation without affecting cell death, proliferation, or adhesion.

This study shows that an APC truncation mutant increases epithelial tissue tension via RhoA/ROCK, impairing apical cell extrusion and potentially contributing to disease.

This study shows that c-Src activation in endothelial cells causes vascular expansion through focal adhesion signaling and localized matrix degradation, which can be inhibited to prevent abnormal vascular growth.

The paper introduces a transgenic Lifeact-EGFP quail line for live imaging of actin dynamics during avian embryogenesis and demonstrates its utility in studying cellular protrusions and supracellular actin structures.