Marcel Doerflinger

The paper develops a CRISPR-based system using Cas9-expressing hepatocytes to study Plasmodium falciparum host interactions, validating its utility for screening host genes involved in infection.

This study identifies TNF and IL-1β as key drivers of endothelial dysfunction and coagulopathy in acute SARS-CoV-2 infection using in vitro and in vivo models.

This paper uses lipid nanoparticles to deliver mRNA encoding intrabodies that inhibit necroptosis and pyroptosis by targeting MLKL and ASC, respectively.

This paper identifies M. ulcerans JKD8049 as a suitable human challenge strain for Buruli ulcer research due to its stability, antibiotic susceptibility, and ability to produce mycolactone.