BiophysicsbioRxivPreprint
Allosteric structural alterations and auto-regulation of Rab5 GEF activity in Rabex5
Janelle Lauer, Alice Cezanne, Giambattista Guaitoli…·Marino Zerial
This study reevaluates the autoinhibition mechanism of Rabex5 by analyzing structural changes and nucleotide exchange activity, revealing new regulatory roles for Ubiquitin binding domains.
DOI 10.1101/562504