Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease
Subhash Kulkarni, Monalee Saha, Jared Slosberg…·Pankaj Jay Pasricha
This study shows that age-related changes in the lineage composition of the enteric nervous system affect gut health, with mesoderm-derived neurons becoming dominant and functional effects on intestinal motility that can be reversed by GDNF.