Author

Roger J. Liang

The University of Texas Southwestern Medical CenterORCID 0000-0002-3950-9520Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Hao ZhuiD· 2 shared Alison Ryan· 1 shared Andrew ChungiD· 1 shared Benjamin R. KrogeriD· 1 shared Boyuan LiiD· 1 shared Daniel J. SiegwartiD· 1 shared Eric Chen· 1 shared Eric CheniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersPhysiology

Hao ZhuORCID

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2 papers

Recent·Most cited

PhysiologybioRxivPreprintJul 28, 2026

The liver compensates for zonal loss of glucose 6-phosphatase to prevent glycogen storage disease

Roger J. Liang, Ling Cai, Phong T. Nguyen…·Ralph J. DeBerardinis

This study shows that localized loss of G6pc1 in liver zones causes local glycogen accumulation but not systemic disease, highlighting organ-wide compensation for metabolic homeostasis.

DOI 10.64898/2026.07.26.740786

mouseexperimental assay

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Cancer BiologySciencePeer-reviewedNov 6, 2025

Liver cancer initiation is dependent on metabolic zonation but decoupled from premalignant clonal expansion

Jason Guo, Roger J. Liang, Andrew Chung…·Hao Zhu

This study shows that liver cancer initiation depends on metabolic zonation but is not linked to premalignant clonal expansion.

36 citationstop 1%

mousebulk RNA-seq

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