Cancer BiologybioRxivPreprint
Loss of Polycomb Repressive Complex 2 function causes asparaginase resistance in T-acute lymphoblastic leukemia through decreased WNT pathway activity
Thomas Lefeivre, Cosmin Tudose, Theodora-Ioana Grosu…·Jonathan Bond
The paper identifies that PRC2 loss in T-ALL reduces WNT pathway activity, leading to asparaginase resistance, which can be overcome by proteasome inhibition.
DOI 10.1101/2023.08.04.552014