Author

Thomas Lefeivre

University College DublinORCID 0009-0005-2689-8175Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Approach:experimental assay· 1 Assay:metabolomics· 1 Research Focus:protein design· 1

Frequent Co-Authors

Colm J. RyaniD· 2 shared Alex von KriegsheimiD· 1 shared Alfonso Bolado‐CarrancioiD· 1 shared Amélie Trinquand· 1 shared Anjan VenkateshiD· 1 shared Barbara De KegeliD· 1 shared Cosmin TudoseiD· 1 shared Giorgio Oliviero· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersSystems Biology

Colm J. RyanORCID

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2 papers

Recent·Most cited

Systems BiologybioRxivPreprintSep 26, 2024

Paralog protein compensation preserves protein-protein interaction networks following gene loss in cancer

Anjan Venkatesh, Niall Quinn, Swathi Ramachandra Upadhya…·Colm J. Ryan

The paper shows that gene loss in cancer is often compensated by paralog protein abundance changes, stabilizing protein-protein interaction networks and creating therapeutic vulnerabilities.

1 citation

humanproteomics

𝕏 PostBluesky

Cancer BiologybioRxivPreprintAug 4, 2023

Loss of Polycomb Repressive Complex 2 function causes asparaginase resistance in T-acute lymphoblastic leukemia through decreased WNT pathway activity

Thomas Lefeivre, Cosmin Tudose, Theodora-Ioana Grosu…·Jonathan Bond

The paper identifies that PRC2 loss in T-ALL reduces WNT pathway activity, leading to asparaginase resistance, which can be overcome by proteasome inhibition.

DOI 10.1101/2023.08.04.552014

humanproteomics

𝕏 PostBluesky