Sympathetic structural and electrophysiological remodeling in a rabbit model of reperfused myocardial infarction
Amanda Guevara, Charlotte E. R. Smith, Lianguo Wang, Jessica L. Caldwell, Srinivas Tapa, Samantha D. Francis Stuart, Betty W. Ma, G. André Ng, Beth A. Habecker, Zhen Wang, Crystal M. Ripplinger
This study investigates sympathetic remodeling in rabbit hearts after reperfused myocardial infarction, finding CSPGs correlate with reduced nerve density but preserved sympathetic responsiveness, leading to increased arrhythmia risk.
American Journal of Physiology-Heart and Circulatory Physiology · Jul 19, 2024Peer-reviewedPhysiology