Charlotte E. R. Smith

This study shows that acute sildenafil administration reduces atrial fibrillation susceptibility in sheep by prolonging refractory periods and altering electrophysiological properties.

This study examines sex differences in rabbit atrial electrophysiology and arrhythmia susceptibility, finding greater APD heterogeneity and cholinergic responses in females and males under different conditions.

This paper develops a computational pipeline to predict sex-specific antiarrhythmic drug strategies for atrial fibrillation by integrating regression and mechanistic modeling of sex-specific cardiac electrophysiology.

This study examines atrial t-tubule development in sheep, showing that despite reduced density in newborns, Ca2+ handling is maintained through increased L-type Ca2+ current and sarcoplasmic reticulum content.

This paper develops and validates sex-specific computational models of human atrial cardiomyocytes to investigate sex differences in atrial fibrillation mechanisms and therapeutic responses.

This study uses computational models to show female atrial cardiomyocytes in AF have higher Ca2+-driven arrhythmia risk than males, with specific interventions identified to address these differences.

This study investigates sympathetic remodeling in rabbit hearts after reperfused myocardial infarction, finding CSPGs correlate with reduced nerve density but preserved sympathetic responsiveness, leading to increased arrhythmia risk.

This study shows chronic nicotine exposure in rabbits increases heart rate, lowers alternans threshold, and reduces sympathetic responses, likely due to hypo-innervation and diminished β-adrenergic responsiveness.