Crystal M. Ripplinger

This study examines sex differences in rabbit atrial electrophysiology and arrhythmia susceptibility, finding greater APD heterogeneity and cholinergic responses in females and males under different conditions.

The paper develops a multi-parametric imaging system to study cAMP, transmembrane potential, and calcium in the heart, showing cAMP activation correlates with electrophysiological responses.

This study shows that increased QT interval variability (QTV) can precede early afterdepolarizations (EADs) due to intrinsic dynamical instability in cardiac cells, offering an early warning signal for arrhythmia risk.

This study investigates sympathetic remodeling in rabbit hearts after reperfused myocardial infarction, finding CSPGs correlate with reduced nerve density but preserved sympathetic responsiveness, leading to increased arrhythmia risk.

This study shows chronic nicotine exposure in rabbits increases heart rate, lowers alternans threshold, and reduces sympathetic responses, likely due to hypo-innervation and diminished β-adrenergic responsiveness.

The paper develops statistical translators to map cardiac myocyte electrophysiological responses across species, validated with experimental data and simulations.