Lianguo Wang

The paper develops a multi-parametric imaging system to study cAMP, transmembrane potential, and calcium in the heart, showing cAMP activation correlates with electrophysiological responses.

This study investigates sympathetic remodeling in rabbit hearts after reperfused myocardial infarction, finding CSPGs correlate with reduced nerve density but preserved sympathetic responsiveness, leading to increased arrhythmia risk.

This study shows chronic nicotine exposure in rabbits increases heart rate, lowers alternans threshold, and reduces sympathetic responses, likely due to hypo-innervation and diminished β-adrenergic responsiveness.

The paper develops statistical translators to map cardiac myocyte electrophysiological responses across species, validated with experimental data and simulations.