PhysiologybioRxivPreprint
Inhibition of mTORC1 by rapamycin results in feedback activation of Akt S473 and aggravates hallmarks of osteoarthritis in female mice and non-human primates
Dennis M. Minton, Aditya R. Ailiani, Michael D.K. Focht…·Adam R. Konopka
This study shows that rapamycin inhibits mTORC1 and activates AktS473 in joint tissues, leading to worsened osteoarthritis in female mice and marmosets.
5 citations