Dudley W. Lamming

The paper shows that in female mice, carbohydrate quality affects metabolic and neurological responses to low protein diets, but not in males.

This study shows that lifelong dietary valine restriction improves healthspan and extends lifespan in male mice but not females, with distinct molecular effects in different tissues.

This study shows that sleeve gastrectomy improves metabolic health, cognition, and Alzheimer's pathology in 3xTg-AD mice by modulating autophagy and insulin signaling.

This study shows that ovariectomy in female mice enhances their metabolic response to a low protein diet, aligning it with males, while castration has little effect on males.

This study examines the effects of restricting individual branched-chain amino acids on Alzheimer's disease progression in 3xTg mice, finding sex-specific cognitive and metabolic benefits.

The paper investigates how dietary restriction of specific essential amino acids affects metabolism and chromatin states in mice, finding distinct effects for methionine, leucine, and isoleucine.

This study shows that ketogenesis is not essential for the metabolic benefits of caloric restriction in mice, as Hmgcs2 deletion does not impair key metabolic adaptations.

This study shows that a low protein diet enhances metabolic health and weight loss in mice after sleeve gastrectomy, challenging current high-protein dietary recommendations.

This study shows that reducing dietary isoleucine improves metabolic health in mice on a Western diet, with distinct molecular responses across sexes and strains.

This study shows that fasting, not just calorie reduction, is necessary for many benefits of caloric restriction in 3xTg mice with Alzheimer's disease.

This study shows that dietary BCAA restriction mitigates metabolic issues and cellular senescence in mice, with tissue-specific effects observed.

The paper shows dietary lipid is deposited in skin, altering its thermal properties and energy regulation within days.

This study investigates how different rapamycin dosing schedules affect physical performance and metabolic outcomes in mice undergoing voluntary exercise training.

This study shows acarbose improves metabolic health and reduces cognitive deficits in Western diet-fed 3xTg mice, suggesting it may help prevent or delay Alzheimer's disease.

This study reveals that calorie restriction's effects on metabolism and molecular processes depend on the timing of measurements relative to feeding, not just diet alone.

This paper introduces FAMY and GRAIL, new metrics for quantifying healthspan in aging mice, showing they improve with interventions like calorie restriction and identify protein restriction as a healthspan-promoting intervention.

This study shows that rapamycin inhibits mTORC1 and activates AktS473 in joint tissues, leading to worsened osteoarthritis in female mice and marmosets.

This study shows that SIRT3 deficiency under caloric restriction increases lifespan but decreases aerobic capacity and mitochondrial function.