Ann M. Benz

This paper characterizes YX84, a novel neuroactive steroid with dual GABA A receptor agonism and NMDA receptor inhibition, showing favorable behavioral tolerability.

The paper investigates the role of δ subunit-containing GABA-A receptors on parvalbumin positive neurons in shaping electrocortical activity during sleep states, finding altered EEG patterns in their absence.

The paper investigates the range of actions of neurosteroid analogues using in silico and in vitro methods, revealing unexpected modulation of multiple targets beyond GABA-A receptors.

This study shows that δ-containing GABAA receptors in PV interneurons regulate their excitability and inhibit pyramidal neurons in the mPFC, affecting network dynamics.

The paper examines how pharmacological manipulations affect the aperiodic exponent of EEG power spectra in mice, finding it is not a reliable marker of excitation/inhibition balance.