Cancer BiologyEMBO Molecular MedicinePeer-reviewed
Mechanisms of resistance to VHL loss-induced genetic and pharmacological vulnerabilities
Jianfeng Ge, Shoko Hirosue, Leticia Castillon…·Sakari Vanharanta
This study identifies HIF1A as a key inhibitor of VHL null cell fitness and shows that combined VHL/HIF1A inactivation can confer resistance to PROTAC-based therapies.