Author

Daniel Muñoz‐Espín

University of CambridgeORCID 0000-0002-0550-9514Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1

Frequent Co-Authors

Anna Dyas· 2 shared Jianfeng GeiD· 2 shared Anna C. ObenaufiD· 1 shared Cissy YongiD· 1 shared David MacíasiD· 1 shared Grant Duncan StewartiD· 1 shared Hui‐Ling OuiD· 1 shared James E. KorkolaiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

Anna Dyas

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Cancer BiologyCell Death and DiseasePeer-reviewedOct 5, 2026

Identification of senescence-associated drivers of tumour growth and progression using a novel microarray platform

Hui‐Ling Ou, Reuben J. Hoffmann, Rebecca Smith…·James E. Korkola

This study identifies SASP factors that drive tumorigenesis in breast and lung cancer cells using a microarray platform and validates their role in growth and survival.

DOI 10.1038/s41419-026-09309-5

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologyEMBO Molecular MedicinePeer-reviewedDec 19, 2025

Mechanisms of resistance to VHL loss-induced genetic and pharmacological vulnerabilities

Jianfeng Ge, Shoko Hirosue, Leticia Castillon…·Sakari Vanharanta

This study identifies HIF1A as a key inhibitor of VHL null cell fitness and shows that combined VHL/HIF1A inactivation can confer resistance to PROTAC-based therapies.

3 citations

humangenetic perturbation / CRISPR

𝕏 PostBluesky

Cell BiologyCell Death and DiseasePeer-reviewedNov 25, 2024

Failed reprogramming of transformed cells due to induction of apoptosis and senescence impairs tumor progression in lung cancer

Pablo Pedrosa, Zhenguang Zhang, Victor Nuñez-Quintela…·Daniel Muñoz‐Espín

The paper shows that OSKM expression in lung cancer cells induces apoptosis and senescence, limiting tumor growth and reducing tumor burden in vivo.

6 citations

mouseexperimental assay

𝕏 PostBluesky