MicrobiologymBioPeer-reviewed
Prodomain-driven enzyme dimerization, a potent pH-dependent autoinhibition mechanism to control Plasmodium Sub1 subtilisin-like activity prior to prime merozoite egress
Mariano Martínez, Anthony Bouillon, Sébastien Brûlé…·Jean-Christophe Barale
This paper identifies a pH-dependent autoinhibition mechanism in Plasmodium Sub1 protease, where the prodomain drives dimerization at acidic pH to regulate enzyme activity prior to merozoite egress.
10 citations