Author

Jean-Christophe Barale

Centre National de la Recherche ScientifiqueORCID 0000-0002-1203-0376Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:structural biology· 1

Frequent Co-Authors

Ahmed HaouziD· 1 shared Anthony Bouillon· 1 shared Bertrand D. E. RaynaliD· 1 shared Mariano MartíneziD· 1 shared Pedro M. AlzariiD· 1 shared Sébastien BrûléiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

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6 top collaborators · 15 mutual co-author links

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1 shared paperMicrobiology

Ahmed HaouzORCID

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1 paper

Recent·Most cited

MicrobiologymBioPeer-reviewedFeb 22, 2024

Prodomain-driven enzyme dimerization, a potent pH-dependent autoinhibition mechanism to control Plasmodium Sub1 subtilisin-like activity prior to prime merozoite egress

Mariano Martínez, Anthony Bouillon, Sébastien Brûlé…·Jean-Christophe Barale

This paper identifies a pH-dependent autoinhibition mechanism in Plasmodium Sub1 protease, where the prodomain drives dimerization at acidic pH to regulate enzyme activity prior to merozoite egress.

10 citations

humanstructural biology

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