ImmunologybioRxivPreprint
Selective killing of plasma cell clones using splice-switching oligonucleotides targeting immunoglobulin variable exons.
Jean-Marie Lambert, Antoine Praité, Marion Contini…·Laurent Delpy
This study shows that splice-switching ASOs targeting V exons in myeloma cells induce selective plasma cell clone death via ER stress and apoptosis.
DOI 10.1101/2024.08.30.610519