Laurent Delpy

This paper develops a mouse model of cardiac AL amyloidosis that reproduces human disease features, including amyloid deposits and cardiac dysfunction, and identifies a role for partial LC degradation in fibril formation.

This study shows that splice-switching ASOs targeting V exons in myeloma cells induce selective plasma cell clone death via ER stress and apoptosis.

This study develops a mouse model of light chain deposition disease, showing that pathogenic light chains cause glomerulosclerosis and kidney failure, and identifies potential therapeutic targets.