Antreas C. Kalli

This paper identifies a molecular switch in the RCK2 domain of KNa1.1 channels that mediates sodium-dependent activation through conformational changes involving specific amino acid residues.

This study uses deep graph neural networks trained on MD simulations to predict phosphoinositide interaction sites on PH domains, achieving results comparable to simulations in seconds.

The paper identifies and characterizes novel PIEZO1 variants associated with GLD, showing they impair mechanosensitivity and demonstrating small-molecule rescue of channel function.