David J. Beech

The paper examines transcriptomic heterogeneity of microvascular endothelial cells in subcutaneous adipose tissue and skeletal muscle in type 2 diabetes, finding stress in SAT but not SkM.

This study shows endothelial Piezo1 promotes mechanical overload-induced muscle hypertrophy by regulating AKT abundance, but not muscle regeneration.

This study presents cryo-EM structures of TRPC5 bound to (-)-englerin A, revealing its binding site and mechanism of activation.

The paper shows that TPC2-mediated Ca2+ release regulates Rab46-dependent Weibel-Palade body trafficking, promoting Ang2 secretion in endothelial cells.

This paper identifies a small molecule that reduces IR:IGF-1R hybrid formation in human endothelial cells, increasing Akt phosphorylation and altering PI3-kinase signaling.

The paper identifies and characterizes novel PIEZO1 variants associated with GLD, showing they impair mechanosensitivity and demonstrating small-molecule rescue of channel function.

The paper reports the cryo-EM structure of human TRPC5 bound to the xanthine inhibitor Pico145, revealing its interaction with a conserved lipid binding site and elucidating the mechanism of TRPC1/4/5 modulation.

The paper investigates the interaction between Piezo1 channels and cell adhesion molecules, showing how this interaction modulates mechanical sensitivity at the subcellular level.