Nadia Pilati

This study identifies two existing drugs that reduce KCNT1 channel activity and seizure activity in Drosophila models, suggesting potential new treatments for KCNT1-epilepsy.

This paper identifies a molecular switch in the RCK2 domain of KNa1.1 channels that mediates sodium-dependent activation through conformational changes involving specific amino acid residues.

This study shows that Kv3.3 subunits regulate presynaptic action potential waveform and neurotransmitter release at the calyx of Held synapse, affecting high-frequency transmission.

The paper identifies four neuronal types in spinal cord lamina VII, showing Kv3 channels are critical for fast firing in interneurons and synaptic inhibition of parasympathetic preganglionic neurons.

This study investigates how epilepsy-causing KCNT1 variants increase KNa1.1 channel activity by disrupting activation and selectivity filter gates.