MicrobiologyMicrobiology SpectrumPeer-reviewed
Repurposing Hsp90 inhibitors as antimicrobials targeting two-component systems identifies compounds leading to loss of bacterial membrane integrity
Blanca Fernandez-Ciruelos, Marco Albanese, Anmol S. Adhav…·Jerry Mark Wells
This study repurposes Hsp90 inhibitors as antimicrobials targeting bacterial two-component systems, finding that DPP analogues disrupt bacterial membranes and show antimicrobial activity against Gram-positive bacteria.