Jerry Mark Wells

This study develops an iPSC-derived urothelial organoid model to investigate how hormones affect host defense against urinary tract infections.

This paper uses metabolomics co-variation networks to analyze urobiome-pathogen interactions, identifying keystone species and emergent pathogen states in a synthetic urobiome model.

This study identifies conditionally essential genes for Streptococcus suis growth in serum and cerebrospinal fluid using Tn-Seq and Nanopore sequencing.

This study shows that high-fiber maternal diets alter gene expression and chromatin accessibility in fetuses and piglets, improving metabolic health and immune tolerance.

This study repurposes Hsp90 inhibitors as antimicrobials targeting bacterial two-component systems, finding that DPP analogues disrupt bacterial membranes and show antimicrobial activity against Gram-positive bacteria.

This study compares transcriptome profiles of pig intestinal organoids from different segments to assess their similarity to in vivo tissues and variability between adjacent sites.