Author

Aigars Jirgensons

Latvijas Organiskās Sintēzes InstitūtsORCID 0000-0002-8937-8792Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Aigars Jirgensons1 paper · National Institute of Reseach and Innovation

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:bacteria (other)· 1 Organism:E. coli· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Alberto MarinaiD· 1 shared Anmol S. AdhaviD· 1 shared Arabela Ritchie-Martinez· 1 shared Ben F. LuisiiD· 1 shared Björn WindshügeliD· 1 shared Blanca Fernandez-CiruelosiD· 1 shared Cristina D. CruziD· 1 shared Emmanouela Petsolari· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperMicrobiology

Alberto MarinaORCID

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintFeb 18, 2025

Disassembly of the Escherichia coli AcrABZ-TolC efflux pump by ligand-mediated disruption of TolC-AcrA interfacial contacts

Tania Szal, Emmanouela Petsolari, Janis Veliks…·Björn Windshügel

The paper identifies a compound that disrupts the TolC-AcrA interface of the E. coli efflux pump, leading to pump disassembly and reduced antibiotic resistance.

4 citations

E. coliexperimental assay

𝕏 PostBluesky

MicrobiologyMicrobiology SpectrumPeer-reviewedJun 25, 2024

Repurposing Hsp90 inhibitors as antimicrobials targeting two-component systems identifies compounds leading to loss of bacterial membrane integrity

Blanca Fernandez-Ciruelos, Marco Albanese, Anmol S. Adhav…·Jerry Mark Wells

This study repurposes Hsp90 inhibitors as antimicrobials targeting bacterial two-component systems, finding that DPP analogues disrupt bacterial membranes and show antimicrobial activity against Gram-positive bacteria.

4 citations

bacteria (other)experimental assay

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