NeuroscienceNeuropsychopharmacologyPeer-reviewed
Repeated restraint stress-induced increase in post-surgical somatosensory hypersensitivity and affective responding is mediated by β-adrenergic receptor activation and spinal NLRP3-IL1β signalling in male rats
Ariadni Bella, Khaled Abdallah, Daniela Rodrígues-Amorím…·Michelle Roche
This study shows that repeated restraint stress worsens post-surgical pain and anxiety in rats through β-adrenergic receptor activation and spinal NLRP3-IL1β signaling.
DOI 10.1038/s41386-025-02305-x