Cancer BiologybioRxivPreprint
Gain-of-function CRISPR screens identify tumor-promoting genes conferring melanoma cell plasticity and therapy-resistance
Arthur Gautron, Laura Bachelot, Anaïs M. Quéméner…·David Gilot
This study identifies tumor-promoting genes via CRISPR screens that confer melanoma cell plasticity and therapy resistance, showing SMAD3's role in BRAFi-resistance and potential as a therapeutic target.
DOI 10.1101/2020.07.08.193102