Author

Austin T. Klein

Northwestern University

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Biochemistry· 1

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Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Approach:wet-lab / biochemical assay· 1

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Daniel James McGrailiD· 1 shared Hardik ShahiD· 1 shared Heather S. Carr· 1 shared Issam Ben‐SahraiD· 1 shared John M. AsaraiD· 1 shared Marc L. MendilloiD· 1 shared Mushtaq Ahmad NengrooiD· 1 shared Nidhi SahniiD· 1 shared

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1 shared paperBiochemistry

Daniel James McGrailORCID

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1 paper

Recent·Most cited

BiochemistryMolecular CellPeer-reviewedOct 28, 2025

Succinate dehydrogenase activity supports de novo purine synthesis

Mushtaq Ahmad Nengroo, Austin T. Klein, Heather S. Carr…·Issam Ben‐Sahra

This study shows that succinate dehydrogenase supports de novo purine synthesis in cancer cells, and its inhibition reduces proliferation by impairing purine biosynthesis and inducing a compensatory salvage pathway.

18 citationstop 3%

humanmetabolomics

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