Hardik Shah

This study identifies AHCY as a key driver of epigenetic and metabolic reprogramming in ZFTA-RELA ependymomas, revealing its role in promoting tumor growth through pyrimidine synthesis and asparagine dependency.

This study shows that MCT1-mediated lactate uptake sustains nucleotide homeostasis in NSCLC, and its inhibition enhances chemotherapy efficacy by exposing a metabolic vulnerability.

This study shows that enhancing pyruvate dehydrogenase activity in aged intestinal stem cells improves their stemness by increasing mitochondrial ATP production.

The paper develops RNA nanotherapeutics targeting TAMC cholesterol metabolism to enhance anti-tumor immunity in glioblastoma.

The paper shows that acetate from gut microbiota maintains acetyl-CoA levels in colonic epithelial cells, preventing age-independent senescence and inflammation.

This study identifies G3P-ChREBP as a mechanism linking Citrin Deficiency to metabolic dysfunction by activating FGF21 and lipogenesis, affecting food and alcohol choices.

This study shows that succinate dehydrogenase supports de novo purine synthesis in cancer cells, and its inhibition reduces proliferation by impairing purine biosynthesis and inducing a compensatory salvage pathway.

This study shows that mitochondrial one-carbon metabolism is essential for TGF-β-induced glycine synthesis and collagen production in lung fibroblasts, suggesting MTHFD2 inhibitors could treat IPF.

This study shows that pancreatic cancer cells in a nutrient-stressed tumor microenvironment develop drug tolerance, and identifies BCL-XL inhibition as a potential therapeutic strategy.

This paper develops a genetically encoded bifunctional enzyme that reduces redox imbalance and lipotoxicity by enhancing Gro3P biosynthesis and glycerol shunt in mammalian cells.

This study investigates the role of arginine and its metabolism in TGF-β-induced activation of lung fibroblasts, finding that arginine depletion inhibits mTORC1 activation and collagen production.

The paper shows MTHFD2 supports creatine synthesis in PTLD models by driving glycine production, and its loss reveals tumor-suppressive effects through metabolic epistasis.

This study identifies phosphoethanolamine as a key metabolite in tumor interstitial fluid that suppresses T cell function by inhibiting TCR signaling.

The paper shows that arginine restriction in the tumor microenvironment limits lipid synthesis in pancreatic cancers, making them susceptible to polyunsaturated fatty acids via ferroptosis.

This study investigates how genetic vitamin B6 deficiency interacts with alcohol consumption in Drosophila, showing altered behavior and metabolism, with potential therapeutic implications.