Cancer BiologybioRxivPreprint
Reviving immunogenic cell death upon targeting TACC3 enhances T-DM1 response in HER2-positive breast cancer
Mustafa Emre Gedik, Ozge Saatci, Nathaniel Oberholtzer…·Ozgur Sahin
This study shows that T-DM1 induces immunogenic cell death (ICD) in HER2-positive breast cancer, which is lost in resistance, and that targeting TACC3 restores ICD and enhances T-DM1 response.
DOI 10.1101/2023.09.12.557273