Mustafa Emre Gedik

This study identifies lysosomal lipid metabolism as a driver of pancreatic cancer cell invasion through local energy production and membrane remodeling.

This study identifies LINC00152 as a driver of tamoxifen resistance in ER+ breast cancer by inhibiting ferroptosis, and shows that targeting LINC00152 restores sensitivity to tamoxifen.

This study shows that T-DM1 induces immunogenic cell death (ICD) in HER2-positive breast cancer, which is lost in resistance, and that targeting TACC3 restores ICD and enhances T-DM1 response.