Cancer BiologybioRxivPreprint
Systematic identification of regulators of antibody-drug conjugate toxicity using CRISPR-Cas9 screens
C. K. Tsui, R. M. Barfield, C. R. Fischer…·M. C. Bassik
This study uses CRISPR-Cas9 screens to identify genes regulating antibody-drug conjugate (ADC) toxicity, revealing endolysosomal trafficking regulators and mechanisms of ADC resistance.
DOI 10.1101/557454