Author

B. A. Lucas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 4 Approach:deep learning· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:protein structure prediction· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Research Focus:benchmarking· 1

Frequent Co-Authors

N. Grigorieff· 4 shared B. A. Himes· 2 shared J. Mahamid· 1 shared K. Zhang· 1 shared L. Xue· 1 shared S. Loerch· 1 shared T. Grant· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 13 mutual co-author links

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4 shared papersBiophysics

N. Grigorieff

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4 papers

Recent·Most cited

Baited reconstruction with 2D template matching for high-resolution structure determination in vitro and in vivo without template bias

B. A. Lucas, B. A. Himes, N. Grigorieff

This paper improves 2D template matching for cryo-EM by reducing template bias and enabling high-resolution structure determination without relying on the template.

bioRxiv · Jul 3, 2023 · PreprintBiophysics

Quantification of gallium cryo-FIB milling damage in biological lamella

B. A. Lucas, N. Grigorieff

This paper quantifies gallium cryo-FIB milling damage in biological lamellae, showing damage extends 60 nm from each surface, limiting structural biology information recovery.

bioRxiv · Feb 1, 2023 · PreprintBiophysics

In situ single particle classification reveals distinct 60S maturation intermediates in cells

B. A. Lucas, K. Zhang, S. Loerch, N. Grigorieff

The paper uses 2DTM to classify 60S ribosome maturation intermediates in yeast cells by analyzing their signal-to-noise ratios in cryo-EM micrographs.

bioRxiv · Apr 10, 2022Biophysics

Locating Macromolecular Assemblies in Cells by 2D Template Matching with cisTEM

B. A. Lucas, B. A. Himes, L. Xue, T. Grant, J. Mahamid, N. Grigorieff

This paper introduces a GPU-accelerated 2D template matching method in cisTEM for identifying macromolecular assemblies in cells, demonstrating its utility for in situ proteomics and structure determination.

bioRxiv · Apr 20, 2021Cell Biology