Achieving Resilience in Aging: How Mitochondrial Modulation Drives Age-associated Fluconazole Tolerance in Cryptococcus neoformans
K. Yoo, N. K. Oliveira, S. Bhattacharya, B. C. Fries
This study identifies mitochondrial metabolic changes in old Cryptococcus neoformans cells that drive fluconazole tolerance through increased ergosterol synthesis and ABC transporter upregulation.
bioRxiv · Mar 26, 2024 · PreprintMicrobiology