G. Garcia

Distinct mechanisms of non-autonomous UPRER mediated by GABAergic, glutamatergic, and octopaminergic neurons.

The paper identifies distinct roles of GABAergic, glutamatergic, and octopaminergic neurons in mediating non-autonomous UPRER through transcriptomic and functional analyses in C. elegans.

High Throughput Screening with a Primary Human Mucociliary Airway Model Identifies a Small Molecule with Anti-SARS-CoV-2 Activity

This study uses a primary human stem cell-based airway model to screen 2100 compounds and identifies a small molecule effective against SARS-CoV-2 and its Omicron variant.

Mechanical stress through growth on stiffer substrates impacts animal health and longevity in C. elegans.

This study investigates the impact of substrate stiffness on C. elegans health and longevity, finding only mild effects on cellular and organismal health.

p110alpha-dependent hepatocyte signaling is critical for liver gene expression and its rewiring in MASLD

This study investigates the role of p110alpha in hepatocyte signaling, showing its critical impact on liver gene expression and its rewiring in MASLD.

Investigating impacts of marine sponge derived mycothiazole and its acetylated derivative on mitochondrial function and aging.

This study investigates the effects of marine sponge-derived mycothiazole and its acetylated derivative on mitochondrial function and aging using in vitro and in vivo models.

Linked regulation of genome integrity and senescence-associated inflammation by p53

This study identifies a mitochondria-regulated p53 circuit that links genomic instability and inflammation in senescent cells, showing p53 suppresses inflammation without affecting cell cycle arrest.

ENDO-LYSOSOME-TARGETED NANOPARTICLE DELIVERY OF ANTIVIRAL THERAPY FOR CORONAVIRUS INFECTIONS

This study develops lysosome-targeted nanoparticles loaded with mefloquine to inhibit coronavirus infection, showing effectiveness against SARS-CoV-2 and its variants in cell models.

Pharmacological activation of constitutive androstane receptor induces female-specific modulation of hepatic metabolism

This study shows that pharmacological activation of CAR leads to sex-specific changes in hepatic metabolism and drug-induced liver injury in mice.

Broad-spectrum antiviral inhibitors targeting pandemic potential RNA viruses

This study identifies broad-spectrum antiviral agents effective against multiple RNA virus families, including arboviruses and respiratory pathogens.

Lipid homeostasis is essential for a maximal ER stress response

This study identifies let-767 as a gene critical for lipid and ER protein homeostasis, showing that lipid metabolism influences the ER stress response.

Large-scale genetic screens identify BET-1 as a cytoskeleton regulator promoting actin health and lifespan.

The paper identifies BET-1 as a regulator of actin health and lifespan through genetic screens in human fibroblasts and C. elegans.

Hippo Signaling Pathway Activation during SARS-CoV-2 Infection Contributes to Host Antiviral Response

This study identifies Hippo signaling pathway activation as an antiviral response to SARS-CoV-2 infection and shows pharmacological targeting of the pathway can reduce virus replication.

Mitoquinone mesylate targets SARS-CoV-2 infection in preclinical models

Mitoquinone mesylate shows antiviral and anti-inflammatory effects against SARS-CoV-2 in preclinical models.

Analysis of nucleic acids extracted from rapid diagnostic tests reveals a significant proportion of false positive test results associated with recent malaria treatment

The paper analyzes nucleic acids from malaria RDTs to show that 4.7% of results were false-negative and 28.4% false-positive, linked to low parasite density and PfHRP2 antigen persistence after treatment.

ORAI1 establishes resistance to SARS-CoV-2 infection by regulating tonic type I interferon signaling

This study shows ORAI1 regulates baseline type I interferon signaling, affecting resistance to SARS-CoV-2 infection.

Antiviral Drug Screen of Kinase inhibitors Identifies Cellular Signaling Pathways Critical for SARS-CoV-2 Replication

This study screens kinase inhibitors to identify compounds that block SARS-CoV-2 replication by targeting key cellular signaling pathways.

A monoclonal antibody against staphylococcal enterotoxin B superantigen inhibits SARS-CoV-2 entry in vitro

This paper shows that an anti-SEB monoclonal antibody inhibits SARS-CoV-2 entry by blocking protease access to the Spike protein's cleavage site.

Evolutionary analysis of SARS-CoV-2 spike protein for its different clades

This study analyzes the evolutionary patterns of SARS-CoV-2 spike protein across seven clades, identifying haplotype diversity and similar evolutionary rates across clades.

Direct exposure to SARS-CoV-2 and cigarette smoke increases infection severity and alters the stemcell-derived airway repair response

This study shows that cigarette smoke exposure increases SARS-CoV-2 infection severity in airway cultures by reducing interferon response and ABSC proliferation.

SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery

The paper develops a primary human lung epithelium infection model to study SARS-CoV-2 pathobiology and screen drugs for COVID-19.

Human iPSC-Derived Cardiomyocytes are Susceptible to SARS-CoV-2 Infection

This study shows SARS-CoV-2 can infect human iPSC-derived cardiomyocytes in vitro, causing apoptosis and loss of beating, and establishes a model for studying infection mechanisms and drug screening.

Podocyte-specific knockout of the neonatal Fc receptor (FcRn) results in differential protection depending on the model of immune-mediated kidney disease

This study shows that podocyte-specific FcRn knockout protects against immune-mediated kidney disease in the NTS model but not the anti-GBM model.

The oldest freshwater crabs: claws on dinosaur bones

This paper describes the discovery of the oldest freshwater crabs, Dinocarcinus velauciensis, from the Upper Cretaceous of France, indicating early freshwater colonization by brachyuran crabs.

Deformed Alignment of Super-Resolution Images for Semi-flexible Structures in 3D

The paper develops a method to align semi-flexible 3D structures from super-resolution microscopy images with high accuracy and efficiency, demonstrating it on STORM images of ciliary distal appendages.

Evolutionary proteomics uncovers ciliary signaling components

The paper uses proteomic analysis of cilia from diverse organisms to identify conserved ciliary proteins and their ancient signaling connections, revealing a novel protein involved in vertebrate development and human disease.

Super-Resolution Microscopy Reveals That Disruption Of Ciliary Transition Zone Architecture Is A Cause Of Joubert Syndrome

This study uses super-resolution microscopy to show that mutations in RPGRIP1L and TCTN2 disrupt transition zone architecture in Joubert syndrome, affecting ciliary protein localization and signaling.