Structural mechanisms for VMAT2 inhibition by tetrabenazine
M. P. Dalton, M. H. Cheng, I. Bahar, J. A. Coleman
This study reports the cryo-EM structure of VMAT2 bound to tetrabenazine, revealing its inhibition mechanism and conformational dynamics.
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6 papers
Recent·Most cited
M. P. Dalton, M. H. Cheng, I. Bahar, J. A. Coleman
This study reports the cryo-EM structure of VMAT2 bound to tetrabenazine, revealing its inhibition mechanism and conformational dynamics.
C. Zhang, X. Zhang, T. Weiss…·A. G. Beck-Sickinger
The paper determines the cryo-EM structure of the CMKLR1-Gi complex with chemerin9, revealing molecular mechanisms of signaling and potential for small molecule agonist development.
C. Chen, J. W. Saville, M. M. Marti…·W. Li
This study identifies a biparatopic VH domain that neutralizes SARS-CoV-2 VOCs, including Omicron, with high potency in vitro and in a mouse model.
M. H. Cheng, R. A. Porritt, M. Noval Rivas…·I. Bahar
This paper shows that an anti-SEB monoclonal antibody inhibits SARS-CoV-2 entry by blocking protease access to the Spike protein's cleavage site.
R. A. Porritt, L. Paschold, M. Noval Rivas…·M. Arditi
This study identifies a skewed TCR repertoire in MIS-C patients, with TRBV11-2 expansion linked to disease severity and superantigen-like interactions with SARS-CoV-2 spike protein.
M. H. Cheng, S. Zhang, R. A. Porritt…·I. Bahar
The paper identifies a SARS-CoV-2 spike protein motif with superantigen-like properties that may contribute to MIS-C and cytokine storms in COVID-19 patients.