This study identifies autophagy as a critical survival pathway in mIDH1 gliomas and shows that inhibiting autophagy enhances radiosensitivity and tumor regression in preclinical models.

bioRxiv · Mar 8, 2024 · PreprintCancer Biology

H3.3-G34R Mutation-Mediated Epigenetic Reprogramming Leads to Enhanced Efficacy of Immune Stimulatory Gene Therapy in Diffuse Hemispheric Gliomas

M. B. Garcia Fabiani, S. Haase, K. Banerjee, Z. Zhu, B. McClellan, A. Mujeeb, Y. Li, C. E. Tronrud, M. L. Varela, M. E. J. West, J. Yu, P. Kadiyala, A. Taher, F. J. NUNEZ, M. S. Alghamri, , Sart

This study shows that H3.3-G34R mutations reprogram the tumor immune microenvironment in diffuse hemispheric gliomas, enhancing the efficacy of immune stimulatory gene therapy and leading to long-term survival in treated mice.

bioRxiv · Jun 13, 2023 · PreprintCancer Biology

Zinc Finger MYND-Type Containing 8 (ZMYND8) is epigenetically regulated in mutant Isocitrate Dehydrogenase 1 (IDH1) glioma to promote radioresistance

S. V. Carney, K. Banerjee, A. Mujeeb, B. Zhu, S. Haase, M. L. Varela, P. Kadiyala, C. Tronrud, Z. Zhu, D. Mukherji, P. Gorla, R. Tagett, F. J. Nunez, M. Luo, W. Lou, , M. G. Castro

This paper identifies ZMYND8 as a gene epigenetically regulated by mIDH1 that promotes radioresistance in glioma cells, and shows its knockdown enhances radiosensitivity.

bioRxiv · Jun 10, 2022Cancer Biology

Systemic delivery of a CXCR4-CXCL12 signaling inhibitor encapsulated in synthetic protein nanoparticles for glioma immunotherapy

M. S. Alghamri, K. Banerjee, A. A. Mujeeb, A. Taher, R. Thalla, B. L. McClellan, M. L. Varela, S. M. Stamatovic, G. Martinez-Revollar, A. Andjelkovic-Zochowska, J. V. Gregory, P. Kadiyala, A. Calinescu, J. A. Jimenez, A. A. Apfelbaum, , M. G. Castro

This paper develops synthetic protein nanoparticles delivering a CXCR4 inhibitor to treat glioma by enhancing immunotherapy and reducing tumor progression.

bioRxiv · Aug 27, 2021 · PreprintCell Biology

SERUM ANTIBODY RESPONSES AGAINST CARBAPENEM-RESISTANT KLEBSIELLA PNEUMONIAE IN INFECTED PATIENTS

K. Banerjee, M. P. Motley, E. Diago-Navarro, B. C. Fries

This study characterizes CPS-specific antibody responses in CR-Kp infected patients and reports cross-reactive properties of these antibodies in vitro and in vivo.

bioRxiv · Sep 18, 2020 · PreprintImmunology

The Role of IgG Subclass in Antibody-Mediated Protection against Carbapenem-Resistant Klebsiella pneumoniae

M. P. Motley, E. Diago-Navarro, K. Banerjee, S. Inzerillo, B. C. Fries

This study compares the efficacy of murine IgG1 and IgG3 monoclonal antibodies against CR-Kp, finding that IgG3 has superior complement-mediated and neutrophil-mediated activity, while IgG1 improves macrophage phagocytosis.

bioRxiv · Jul 24, 2020Immunology

Loss of microbial diversity and body site heterogeneity in individuals with Hidradenitis Suppurativa

A. M. Schneider, L. C. Cook, X. Zhan, K. Banerjee, Z. Cong, Y. Imamura Kawasawa, S. L. Gettle, A. L. Longenecker, J. S. Kirby, A. M. Nelson

This study examines microbial diversity and skin niche heterogeneity in HS patients compared to healthy individuals, finding reduced diversity and altered metabolic pathways.

bioRxiv · Apr 18, 2019Microbiology

Elucidating interplay of speed and accuracy in biological error correction

K. Banerjee, A. B. Kolomeisky, O. A. Igoshin

This study develops a stochastic framework to analyze speed and accuracy trade-offs in DNA replication and tRNA selection, finding that biological systems often prioritize speed over accuracy when errors are tolerable.

bioRxiv · Jan 24, 2017Biophysics