A Multiomic Analysis Reveals How Breast Cancers Disseminated to the Bone Marrow Acquire Aggressive Phenotypes through Tumor-Stroma Tunnels
S. Sinha, B. Callow, A. Farfel, S. Roy, S. Chen, S. Rajendran, J. Buschhaus, K. E. Luker, P. Ghosh, G. D. Luker
This study identifies GIV as a key protein transferred from mesenchymal stromal cells to ER+ breast cancer cells via tunnelling nanotubes, driving aggressive tumor phenotypes.
bioRxiv · Mar 18, 2023Cancer Biology